THE ACLARA STUDY

Prevalence, Epidemiology, Characterization and Mechanisms of Acute-on-Chronic Liver Failure (ACLF) in LAtin AmeRicA. Comparison with data from other regional studies (Europe and Asia) (ACLARA” Study)

Observational study Flair Carrilho (University of São Paulo School of Medicine. São Paulo, Brazil)
Richard Moreau (EF Clif. Barcelona, Spain)
Alberto Queiroz Farias (University of São Paulo School of Medicine. São Paulo, Brazil)

Promoter: EF Clif
Start date: 18/05/2020
End date: 30/12/2021

The ACLARA Study is a prospective follow-up observational investigation in 1,300 cirrhotic patients, hospitalized for AD with and without ACLF at 56 hospitals, aimed to assess the characteristics of the ACLF in Latin America. Standard laboratory data and one-year clinical course were recorded to measure mediators, biomarkers, genotyping and make transcriptomics and metabolomics analysis.

Recruitment was planned to be closed in the 3rd quarter of 2020. But due to the COVID-19 pandemic, it was stopped in March 2020. Patients were screened and enrolled from June 2018 to March 2020. A total of 1,285 were eventually enrolled. Demographic and general characteristics, data related to the past medical history, clinical data at enrolment and standard laboratory analysis -including biomarkers of systemic inflammation, measurements estimating organ function and severity scores- were collected. After the cleaning of the database, the first paper has been prepared. It describes the prevalence and survival of ACLF from a Latin American cohort. Additionally, it characterizes ACLF in these populations, including clinical course severity and relationship between ethnicity distribution, lifestyle and other features related to geographic and environmental variations.