Liver Transplantation in patients with CirrHosis and severe ACLF: iNdications and outComE (CHANCE), a global study in Europe, Latin America, North America, China, India, Taiwan, Japan and Korea.
Non-observational without drugs
Thierry Gustot (HUB Erasme. Brussels, Belgium)
Javier Fernández (Hospital Clínic Barcelona-IDIBAPS; EF Clif. Barcelona, Spain)
William Bernal (King’s College. London, United Kingdom)
Promoter: EF Clif
Start date: 01/10/2020
End date: 31/12/2025
CHANCE is a multicentre, international, observational study, designed to assess the results of liver transplantation in patients with Acute-on-Chronic Liver Failure grade 2 or 3. It will recruit 3,000 patients around the world.
The final version of the protocol was validated by the Scientific board in December 2020. The participating centres (95) were selected by a feasibility questionnaire on clinical data and sample collection, around the world. The electronic CRF will be finalized ad the beginning of 2021. The first approval by ethical committee was obtained in February 2021 in Hospital Clinic, Barcelona. The recruitment will start in the second quarter 2021 for three countries: Spain, India and United Kingdom.